Significance of the PI3K/AKT pathway in coronary microvascular dysfunction and advances in natural compound therapeutic research
Introduction: Coronary microvascular dysfunction (CMD) contributes to myocardial ischemia and adverse cardiovascular outcomes, but effective treatments remain limited. Objective: This review aims to clarify the role of the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway in CMD and assess the therapeutic p...