Open access
Aug 2026
A Molecular Mechanistic Deep Dive into 14-3-3 Molecular Glue Cooperativity.
These findings establish cooperativity, intrinsic PPI affinity, and MG affinity as key parameters governing MG activity and selectivity, providing a framework for the rational design of MGs targeting hub protein interactomes.
Marloes A. M. Pennings, Edmee M. F. Vandenboorn-Bönner, Lisa Nooren et al.
· Biochemistry · 0 citations