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Author

Lisa Miorin

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Open access Sep 2026

The Hao-Fountain syndrome gene USP7 restricts neurotropic orthoflavivirus entry through cell-intrinsic control of endosomal dynamics

Neurodevelopmental disorders are increasingly associated with immune phenotypes, including autoinflammation, immunodeficiency, and increased susceptibility to severe infection. To determine whether neurodevelopmental disorders-associated genes exert immune functions, we performed an arrayed siRNA screen targeting 28 ge...

Boris Bonaventure, Kyna Reyes, M. Martin et al. · 0 citations
Open access Aug 2026

Mutations in SARS-CoV-2 Nsp1 are critical determinants of viral pathogenicity in mice

The reduced pathogenicity of rSARS-CoV-2 Nsp1 mutants highlights the potential for targeting Nsp1 for rational design of viral inhibitors and development of live-attenuated vaccine strategies as effective prophylactic and therapeutic treatments to combat SARS-CoV-2 and possibly other CoV infections.

Nathaniel Jackson, Fu-Chun Zhou, Anastasija Cupic et al. · 0 citations

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