Author

Lisa M. Jenkins

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Open access Aug 2026

SV40 Large T antigen inhibits the host serine protease FAM111A through a zinc-dependent, cleavage-avoiding mechanism

The X-ray crystal structure of the FAM111A serine protease domain in complex with LT-C is reported, revealing the structural basis for direct inhibition of FAM111A and defining a zinc-dependent, cleavage-avoiding mechanism of protease inhibition that highlights an evolutionary arms race between SV40 and host antiviral...

Allison L. Welter, S. Dharavath, Yuka Machida et al. · bioRxiv · 0 citations

#protein folding Open access Aug 2026

16S ribosomal RNA modification drives transcript-specific translation efficiency

It is proposed that MraW modification of 16S rRNA enhances translation efficiency in general, and that specific transcripts have evolved structural features that fine-tune protein levels that may be prevalent in bacteria which exhibit uncoupled transcription and translation.

Zachory M. Park, Christina R. Savage, Amanda R. Decker-Farrell et al. · Cell Reports · 0 citations