Open access
Aug 2026
NACraft: Programmatic nucleic-acid aptamer design via all-atom structure-model feedback
NACraft, a training-free and programmatic framework for all-atom nucleic-acid aptamer design based on backpropagation through structure-model feedback, is presented, demonstrating the effectiveness and versatility of NACraft and extending structure-model hallucination toward programmatic nucleic-acid aptamer design.
He-Qin Zhu, Jiaqi Wang, Wei-Bo Zhao et al.
· bioRxiv · 0 citations