Author

Linnea Johnson

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Open access Jul 2026

Sex-specific developmental phenotypes and their response to neonatal Dyrk1a reduction in the Ts65Dn Down syndrome mouse model

Dyrk1a normalization in Ts65Dn pups did not improve all abnormal phenotypes, perhaps because of developmental dysregulation between Dyrk1a RNA and DYRK1A protein levels, involvement of other trisomic genes, or improvements in only adult mice.

Alyssa Duerst, Laura E. Hawley, Linnea Johnson et al. · bioRxiv · 0 citations