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Lingbing Zhang

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Review Open access Aug 2026

Cancer Cachexia Research and Drug Development: Lessons from Failures and the Promise of Immunomodulation

This review summarizes the progression of cachexia research, highlighting key findings involving inflammatory cytokines, proteolytic pathways, mitochondrial dysfunction, and immune dysregulation, and novel immunomodulatory strategies, including R-ketorolac, which may restore immune homeostasis and target the root causes of cachexia.

Lingbing Zhang, Jeffrey A. Norton · 0 citations

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