Objective To compare the efficacy and safety of telitacicept as add-on therapy versus standard of care (SOC) alone in immunosuppressant (IS)-naïve patients with lupus nephritis (LN) and in patients with refractory LN. Methods In this bicentric, real-world, retrospective, triple-cohort study, we enrolled IS-naïve LN pat...
Su-Ren Lai, Shan-Shan Li, Jia-Ying Cai et al.· Frontiers in Immunology· 0 citations
Pentraxin 3 (PTX3), the prototypical long pentraxin, is a locally inducible soluble pattern-recognition molecule that participates in complement regulation, efferocytosis, extracellular-matrix organization, vascular homeostasis, host defense, and tissue repair. These properties have made PTX3 an attractive candidate bi...
Hong-Hao Guo, Wen-Wei Liu, Wang Xiang et al.· Journal of Autoimmunity· 0 citations
Ageing remodels the neuroimmune, metabolic, and vascular environment in ways that accelerate neuronal vulnerability and constrain tissue repair. Mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) are therefore attractive candidates for neurodegenerative disorders because their effects ext...
Glutathione peroxidase 4 (GPX4) is a selenocysteine (Sec)-containing antioxidant enzyme and the only known mammalian enzyme capable of directly reducing membrane-embedded phospholipid and cholesterol hydroperoxides. It is recognized as a central regulator of ferroptosis, modulating cellular redox balance and influencin...
Qian-Yue Yang, Yan-Fu Xia, Yong Wu et al.· Frontiers in Pharmacology· 0 citations
Serum CRP levels showed a disease specific distribution across AIDs, with the highest levels in hyperinflammatory conditions such as AOSD and MAS, suggesting their potential as disease-specific biomarkers.
Qian-Yue Yang, Yu-Lu Zhang, Xiaomin Li et al.· Frontiers in Immunology· 0 citations
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