Preconditioning induces ischemic tolerance by attenuating ferroptosis: involvement of the m6A-dependent FTO-IGF2BP1/3-ACSL4 regulatory Axis.
Cerebral ischemic preconditioning (CIP) confers robust protection against subsequent ischemic stroke by enhancing brain ischemic tolerance. Although ferroptosis is increasingly recognized as a critical pathogenic mechanism in stroke, the role of N6-methyladenosine (m6A) RNA modification in its regulation remains poorly...