Breast cancer remains the leading cause of cancer death among women worldwide, and metabolic reprogramming is increasingly recognized as a hallmark of this disease. Folylpolyglutamate Synthase (FPGS), a key enzyme in folate metabolism, catalyzes the polyglutamylation that retains folate inside cells; however, its role...
Ze-Hao Cai, Han Li, Yang Liu et al.· Cellular Signalling· 0 citations
Background: Triple-negative breast cancer (TNBC) is exceptionally aggressive, with a high recurrence rate, resistance to chemotherapy, and a tendency to metastasize. The long non-coding RNA growth arrest-specific 5 (GAS5) is associated with TNBC progression; however, the specific mechanism still requires further explor...
Jun-Ze Du, Xin He, Ling-Feng Tang et al.· Cancers· 0 citations
A new CEBPB-VASN/IGF2BP3/USP10-ABCB1 axis responsible for paclitaxel resistance in TNBC is uncovered, offering a rationale for precision medicine in resistant TNBC.
Hao-Qi Liu, Zexiu Lu, Mao-Shan Chen et al.· International Journal on Bio...· 0 citations
GPR19 functions as a novel oncogenic driver and clinically relevant biomarker in breast cancer, particularly in TP53-mutant and TNBC subsets, and was significantly upregulated in TP53-mutant breast cancer, primary tumors, and especially TNBC.
Jihan Qiu, Cheng Tian, Hanzhi Li et al.· Frontiers in Bioscience· 0 citations
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