Author

Ling-Bo Zhou

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Open access Sep 2026

LAWS-HiC: A Locally Adaptive Weighting and Screening (LAWS) Approach to Improve Detection of Long-Range Chromatin Interactions from Hi-C Data

Hi-C technologies are widely used to study genome-wide chromosome spatial organization. Among various Hi-C data analyses, detecting long-range chromatin interactions (i.e., 3D peak calling) is particularly critical due to its direct relevance to gene regulation. However, most existing peak callers fail to account for s...

Ling-Bo Zhou, Chang Chen, Jane Zizhen Zhao et al. · Methods and Protocols · 0 citations

Open access Sep 2026

3D epigenome of glial cell types in developing human cortex

A comprehensive three-dimensional epigenomic analysis of four main glial populations, including vRG, oRG, oligodendrocyte precursor cells and microglia, from the mid-gestational human neocortex identifies cell-type-specific candidate cis-regulatory elements (cCREs) and validated their regulatory function using transgen...

Ian R. Jones, Li Wang, M. Kosicki et al. · Nature · 0 citations