Author

Linzhi Tan

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Open access Oct 2026

Protease-Responsive Condensation of Engineered Proteins Drives Tumor-Targeted T-Cell Activation.

Liquid-liquid phase separation (LLPS) drives the formation of biomolecular condensates, which are fundamental to cell signaling. Extracellular phase separation is emerging as a potent strategy for cell-specific signaling modulation; however, its application is limited by the lack of control over on-demand condensate fo...

Qiang Lu, Ke-Rui Zhao, Zi-Feng Qiao et al. · Angewandte Chemie · 0 citations

Open access Aug 2026

A Tumor-Microenvironment-Responsive Chemically Masked IL‑2 Prodrug Potentiates PD‑1 Checkpoint Blockade and Elicits Robust Antitumor Efficacy

A chemically masked IL-2 prodrug (Cm-proIL2) that enables tumor-microenvironment-responsive cytokine activation through tumor-associated protease cleavage to demonstrate the feasibility of chemically masked, tumor-responsive cytokine activation as a strategy for improving the therapeutic index of IL-2-based immunothera...

Linzhi Tan, Yuning Yang, Ke-Rui Zhao et al. · ACS Central Science · 0 citations