Sep 2026
Optimization of AsCas12f1-Mediated Long-Term Gene Repression.
A compact and programmable epigenome editor can be utilized for long-term gene silencing, which becomes a powerful tool for biological research or biomedical applications. Here, we present an enhanced CRISPR-based epigenome editor based on deactivated AsCas12f1 (dAsCas12f1) variants, which incorporate epigenetic modula...
Yang-Yang Sun, Lin-Yung Li, Xiang-Nan Wang et al.
· Molecular Therapy · 0 citations