Author

Lin-Lin Xie

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Open access Sep 2026

Library strategies differentially shape microbial, functional, and host signals in clinical metagenomic sequencing

ABSTRACT Metagenomic next-generation sequencing (mNGS) is increasingly used in infectious disease diagnostics, yet how library preparation shapes the microbial, functional, and host signals recovered from clinical samples remains poorly defined. Here, we performed a within-sample parallel comparison of three mNGS libra...

Geng-Yan Luo, Jin Zhao, Lin-Lin Xie et al. · mSystems · 0 citations

Aug 2026

Terazosin Alleviates Apoptosis and Neuroinflammation in Cerebral Ischemia-reperfusion Injury via Activating the PI3K/AKT/mTOR Signaling Pathway.

BACKGROUND Ischemic stroke remains a major cause of disability and death worldwide, and effective neuroprotective treatments are urgently needed. This study investigated whether Terazosin (TZ), a clinically approved drug with neuroprotective potential, ameliorated Cerebral Ischemia-Reperfusion Injury (CIRI) and explore...

Lin-Lin Xie, Yu-Kun Ping, Jie Zhao et al. · Current Neuropharmacology · 0 citations