Review
Open access
Oct 2026
From density to spatial function: spatial multi-omics, composite biomarker design, and therapeutic engineering of tertiary lymphoid structures in solid tumors
This review synthesizes recent advances in spatial biology that support a shift from counting TLSs to interpreting them as spatially organized immune microenvironmental units embedded within local tumor ecosystems and outlines a staged, module-matched composite biomarker workflow combining digital pathology, targeted m...
Xu-Chen Wang, Lin Lin
· Frontiers in Immunology · 0 citations