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Author

Lin Huang

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Open access Sep 2026

Structure and mechanism of HDV ribozymes revealing Lewis acid catalysis by a metal ion

We have determined the molecular structure and investigated the catalytic mechanism of two ribozymes of the Hepatitis delta virus family, found in the nematode Caenorhabditis briggsae and virus Ackermannviridae. Crystal structures of both conform to the double-pseudoknot architecture adopted by the viral HDV ribozyme....

Yu-Hang Luo, Xiao-Xue Chen, Xiao-Wei Lin et al. · 0 citations
Aug 2026

CoCoBind: Consistency-Contrastive Multitask Learning for RNA–Ligand Interaction and Binding Site Prediction

CoBind is presented, a multitask deep learning framework that jointly predicts RNA–compound interactions and nucleotide-level binding-site probabilities within a unified architecture and provides complementary nucleotide-level binding-site localization, supporting a site-aware view of RNA–ligand recognition under distr...

Shihang Wang, Lin Wang, Wei Zhao et al. · 0 citations

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