Author

Linhong Jin

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Aug 2026

Design, Synthesis, and Antifungal Activity of Novel Oxadiazole-Pyrazole-Triazole Derivatives: Insights into Cellular Disruption Revealed by Integrated Transcriptomic and Proteomic Analyses.

Resistance to single-target fungicides necessitates structurally innovative antifungal agents with broadened modes of action. Herein, a series of pyrazole-oxadiazole-linked 1,2,4-triazole derivatives (L1-L39) were designed and synthesized via molecular hybridization. Compound L22 exhibited exceptional activity against...

Fa-li Wang, Xiao-li Ren, Lin Gao et al. · Journal of Agricultural and... · 0 citations

Jul 2026

Design, Synthesis, and Antifungal Activity of Thiazolidinedione Derivatives Incorporating Thioamide and Piperidine Moieties.

A series of thiazolidinedione derivatives containing thioamide and piperidine moieties were designed, synthesized, and evaluated for antifungal activity against plant pathogenic fungi. Several compounds exhibited potent antifungal activity, among which Z17 was the most active against Rhizoctonia solani (EC50 = 1.8 μg/m...

Junrong Song, Shuang Feng, Miaohe Zhang et al. · Journal of Agricultural and... · 0 citations

Aug 2026

Novel Flavonol Derivatives Bearing a 1,2,3,4-Tetrahydroquinoline Moiety: Design, Synthesis, and Anti-Phytophthora capsici Activity.

Mechanistic studies revealed that Q8 disrupted cell membrane integrity and inhibited succinate dehydrogenase (SDH) activity, with computational simulations suggesting a higher binding affinity for SDH than fluopyram.

Qingxue Hu, Xiaoting Geng, Fang Tian et al. · Journal of Agricultural and... · 0 citations