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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Lin-Feng Li

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Open access Sep 2026

High‐throughput identification of carboxylate‐free ligands for the E3 ligase Kelch domain‐containing protein 2

It is demonstrated that KLHDC2 can accommodate non-carboxylate scaffolds and expands the chemical space for developing KLHDC2-based targeted protein degradation strategies and expands the chemical space for developing KLHDC2-based targeted protein degradation strategies.

Yao Chen, Rui-Chen Gao, Jia-Jia Li et al. · 0 citations
Jul 2026

Structure-Guided Discovery of Novel Dual-Site FEM1B Ligands and Assessment of Their Use in Targeted Protein Degradation.

This work developed FL47, a dual-site ligand that combines extensive noncovalent interactions with targeted covalent engagement that exhibits submicromolar affinity, robust cellular target engagement, and markedly reduced cytotoxicity relative to previously reported covalent recruiters.

Ling-xiang Xu, Ruyi Huang, Yu-Ying Ma et al. · 0 citations

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