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Author

Lin-Cai Ye

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Open access Sep 2026

Right ventricular pressure overload disturbs T-tubule maturation via MEF2D’s transcriptional regulation of BIN1

Right ventricular pressure overload (RVPO) is a critical pathophysiological feature of numerous pediatric cardiovascular diseases. Transverse tubules (T-tubules) form the foundation for efficient excitation-contraction coupling in mature cardiomyocytes. We hypothesized that RVPO impairs T-tubule maturation through the...

Yu-Qing Hu, Yi-Ting Xue, Xu-Dong Chen et al. · 0 citations
Sep 2026

Disrupted blood-brain barrier maturation links congenital heart diseases to hippocampal injury: Insights from a translational neonatal mouse model.

BACKGROUND Neurodevelopmental impairment is the most common non-cardiac morbidity in children with congenital heart diseases (CHDs), yet its pathogenic mechanisms remain poorly understood due to a lack of disease-specific animal models. Right ventricular outflow tract obstruction (RVOTO) is a prevalent CHD lesion. We i...

Yi-Ting Xue, Hao Li, Shi-Qi She et al. · 0 citations

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