Sep 2026
KAT2B epigenetically activates GSTZ1 via H3K9ac to suppress proliferation and stemness and enhance ferroptosis in oral squamous cell carcinoma.
It is found that KAT2B transcriptionally activates GSTZ1 in a H3K9ac-dependent manner, which in turn inhibits GPX4 expression, thereby suppressing OSCC proliferation and stemness while enhancing ferroptosis sensitivity.
Tong Sha, Kun Jiao, Jia-Ning Li et al.
· Biochemical Pharmacology · 0 citations