Author

Lijie You

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Review Open access Oct 2026

Spatial and single-cell insights into the prostate cancer microenvironment: overcoming immunotherapy resistance through multidimensional strategies

Despite breakthroughs in immune checkpoint inhibitors (ICIs) across various malignancies, prostate cancer (PCa), particularly metastatic castration-resistant prostate cancer (mCRPC), has shown limited responses to ICIs. This pervasive primary resistance is fundamentally driven by the canonically “immune-cold” and highl...

De-Kai Liu, Jun-Liang Tang, Yi-Wei Jiang et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

CAF-derived TGF-β1 activates an LBH-mediated β-catenin stabilization program to drive gastric cancer progression

It is shown that the transcriptional cofactor LBH drives mutation-independent Wnt activation and malignant progression in GC via a tumour microenvironment-regulated post-translational stabilization mechanism, elucidate a critical tumour–stroma crosstalk mechanism and establish the targeted disruption of the LBH–β-caten...

Zhi-Xiong Su, Guifeng Zhang, J. Zhong et al. · Cell Death & Disease · 0 citations