RUNX1 silencing protects against cerebral ischemia/reperfusion injury-induced endoplasmic reticulum stress, inflammation, ferritinophagy and ferroptosis through the CELF2/mTOR axis.
Ischemic stroke is a prevalent cerebrovascular disease and remains a major cause of chronic disability and death worldwide. Runt-related transcription factor-1 (RUNX1) is a critical member of the core-binding factor family abnormally elevated in ischemic brain tissue. However, the exact roles of RUNX1 and its underlyin...