Author

Lieza M. Chan

2 papers indexed here

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Oct 2026

Reverse transcribed ssDNA derepresses translation of a retron antiviral protein.

Retrons are bacterial immune systems that prevent phage propagation by initiating a toxic response within infected hosts. Previously characterized retrons produce abundant multicopy single-stranded DNA (msDNA) by reverse transcription, which acts as an antitoxin in the absence of phage. However, we describe here a non-...

Karen Zhang, Matías Rojas-Montero, Darshini Poola et al. · Molecules and Cells · 0 citations

Aug 2026

Small-molecule activation of the tumor suppressor kinase LKB1 via the pseudokinase STRAD.

The ability to target oncogenic signals has transformed oncology. Targeted therapies typically inhibit oncogenic kinases and GTPases. Therapeutic augmentation of tumor-suppressive signaling could be a viable alternative but poses challenges. Specifically, designing compounds capable of stimulating kinase activity is mo...

Lin Song Kretschmer, Dominique C. Mitchell, Jin Liu et al. · Cell Chemical Biology · 1 citation