Integrative 3D genome and epigenomic analysis identifies TP53RK and SYBU as critical regulators of stemness and anti-tumor immunity in HCC.
Three-dimensional (3D) genome organization plays a fundamental role in governing gene regulation and tumor cell properties. However, how higher-order chromatin architecture regulates stemness in hepatocellular carcinoma (HCC) remains unclear. Here, we delineated the 3D chromatin landscapes of well- and poorly different...