Open access
Aug 2026
A cuproptosis-inducing covalent organic framework synergizes with oncolytic virus for tumor radiotherapy
Acquired radioresistance limits effective radiotherapy. Cuproptosis is a copper-dependent form of cell death driven by mitochondrial copper accumulation and lipoylated protein aggregation. Building on evidence that radioresistant cancer cells exhibit increased cuproptosis susceptibility, here we combine a radiation-res...
Yuantong Liu, Ke-Er Liu, Han-Qi Li et al.
· Nature Communications · 0 citations