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Author

Liang Sun

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Sep 2026

Isoschaftoside improves white matter injury via TREM2-mediated phagocytosis and anti-inflammatory effects.

BACKGROUND Ischemic white matter injury (WMI) is a core pathological mechanism underlying vascular cognitive impairment, for which effective clinical interventions are currently lacking. The natural flavonoid glycoside Isoschaftoside (ISO) has been reported to exhibit various pharmacological activities, but its effects...

Cheng-Gang Li, Yu-Hao Xu, Huai-Ping Tang et al. · 0 citations
Aug 2026

Carabrone alleviates neuroinflammation by covalently targeting ubiquitin conjugating enzyme UBE2D3 in experimental autoimmune encephalomyelitis.

Multiple sclerosis (MS) is an incurable and progressive inflammatory disease of the central nervous system (CNS) characterized by inflammatory demyelination, chronic axonal damage, and neurodegeneration. Carabrone (CA), a sesquiterpene lactone from the traditional Chinese herb Carpesium abrotanoides L., demonstrates di...

Huai-Ping Tang, Liang Sun, Bin Jia et al. · 0 citations
Aug 2026

Microglial RIOK3 promotes post-ischemic neuroinflammation by facilitating YBX1 phosphorylation and nuclear accumulation.

Excessive activation of microglia exacerbates secondary brain injury after ischemic stroke, yet the upstream mechanisms governing this response remain incompletely understood. This study aimed to investigate the role of RIO kinase 3 (RIOK3) in microglia-mediated neuroinflammation after ischemic stroke and to explore th...

Yang Geng, Ningning Zong, Chao Zhou et al. · 0 citations

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