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Serum creatinine levels and depressive symptoms were independently associated with global cognition and processing speed and diabetes was independently associated with processing speed.
Brain aging provides an integrative marker of systemic health, but whether regional patterns outperform whole-brain approaches remains unknown. Here, we show that regional brain age signatures achieve superior mortality prediction through identifiable neurovascular-immune mechanisms in 1,240 community-dwelling adults f...
Objectives Population aging is accompanied by increasing heterogeneity in health trajectories and mortality risk. We aimed to identify and compare independent predictors of 3-year and 5-year all-cause mortality in Taiwanese adults aged ≥50 years, integrating intrinsic capacity (IC), functional status, laboratory biomar...
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