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Built with VRH, VenusREM2 is the first to rank highest in all function, taxon, MSA-depth, and mutation-depth categories, with a ProteinGym Average Spearman of 0.556, 0.038 above the prior best.
MAXWELL (Matrix-wise Landscape Learning), a novel post-training method that calibrates the probabilistic outputs learned by protein language models during pretraining to generate mutational landscapes that quantify the effects of individual amino acid substitutions on protein stability, is introduced.
SciReasoner is introduced, a multimodal scientific foundation model for native structural reasoning across proteins, small molecules and inorganic crystals that connects accurate prediction with interpretable scientific inference.
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