Microbial production of l-arginine is often constrained by tight metabolic regulation and insufficient precursor supply. Here a plasmid-free, non-auxotrophic Escherichia coli strain for high-level production of l-arginine was rationally engineered, based on our previous constructed strain G0 with 12.4 g/L l-arginine pr...
Xin Gao, An-Yi Wu, Zi-Teng Yang et al.· Bioresource Technology· 0 citations
d-Pantothenic acid (D-PA) is an essential precursor of coenzyme A and the acyl carrier protein. Its biosynthesis requires abundant precursors and precise regulation of the multifunctional enzyme, ketopantoate reductase. Here, we engineered Corynebacterium glutamicum for enhanced D-PA production through metabolic engi...
Qing Yang, Bo Zhang, Liang-Gang Huang et al.· ACS Synthetic Biology· 0 citations
This study establishes a robust chassis for sustainable DPA production and provides a generalizable framework for engineering other valuable biochemicals.
Qing Yang, Tao-Shun Zhou, Bo Zhang et al.· Biotechnology and Bioenginee...· 0 citations
An integrated strategy combining protoplast-based strain evolution, medium optimization, and transcriptomic analysis to enhance adenosine biosynthesis in P. hepiali is developed and transcriptomic insights into adenosine biosynthesis are provided and a practical framework for improving fungal nucleoside cell factories...
Aiping Pang, Xin Li, Peng-Fei Zhang et al.· Biotechnology and Bioenginee...· 0 citations
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