Synthesis, Preclinical Evaluation, and Clinical Application of the FAPI-Dimer Based on the LARM Platform.
Fibroblast activation protein (FAP) is a promising pan-tumor target for theranostics, but current FAP-targeted radioligands are limited by insufficient tumor retention and suboptimal therapeutic doses. To address these challenges, we developed a novel LARM platform and synthesized the FAPI dimer TH2103-100. The radioch...