Liang Chen

From local control to systemic management: radiotherapy and sequential methotrexate therapy in an adult BRAF-negative hypothalamic-pituitary Langerhans cell histiocytosis – a case report with 15-month follow-up

This case illustrates that involved-field IMRT can achieve durable local control of HPR-LCH even in BRAF V600E-negative cases, but local control does not equate to systemic cure; close surveillance for extracranial progression is essential, and timely systemic chemotherapy is critical for managing multisystem disease.