Tissue repair is a highly coordinated process, yet dysregulated fibrosis often diverts healing toward scar formation, resulting in permanent structural and functional impairment. Achieving scarless regeneration requires precise modulation of the wound microenvironment to support functional tissue reconstruction. Hydrog...
Shuang-Li Zhu, Ying-Xun Shi, Hao-Ran Wang et al.· Bioactive Materials· 0 citations
This review summarizes current advances in metal-ion-mediated cGAS-STING activation and examines how metal ions and metallic nanostructures integrate agonist delivery, intrinsic pathway activation, and tumor microenvironment modulation.
Yun-Qi Guo, Zhi-Hao Zhao, Liang-Can He et al.· ACS Nano Medicine· 0 citations
Radioimmunotherapy holds great promise for the treatment of solid tumors. However, radioresistance and immunosuppression mediated by a tumor microenvironment (TME) severely restrict radiation-induced immunogenic cell death (ICD), facilitate tumor relapse and metastatic dissemination, and ultimately compromise the the...
Yunsong Wang, Nannan Zheng, Shujuan Liu et al.· ACS Nano· 0 citations
In vivo studies in diabetic Sprague-Dawley rats model demonstrated that CC-pMnO2-Vet@PNAA established a coordinated immune-mechanical microenvironment, achieving rapid and scar-free wound healing.
