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Author

Lian-Xiang Luo

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Oct 2026

HIF-1α-Driven Protein Lactylation Promotes Ferroptosis and Lipid Peroxidation in Ulcerative Colitis and Is Suppressed by Quercetin.

Ulcerative colitis (UC) is associated with a hypoxic microenvironment that stabilizes hypoxia-inducible factor-1α (HIF-1α), driving glycolytic flux and lactate accumulation. Ferroptosis, an iron-dependent cell death process linked to lactate metabolism, has been implicated in UC pathogenesis; however, whether HIF-1α re...

Chu-Chu Yan, Wei-Wei Wang, Jing-Li Ao et al. · 0 citations
Review Aug 2026

Ferroptosis in Intestinal Diseases: Molecular Mechanisms, Therapeutic Potential, and Future Perspectives.

This review systematically integrates the latest insights into the molecular mechanisms regulating ferroptosis, the pathophysiology of various intestinal diseases, and translational therapeutic strategies to provide a comprehensive roadmap for leveraging ferroptosis to manage intestinal diseases.

Liyan Deng, Kangdi Liu, Jia-Li Peng et al. · 0 citations

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