Lian-Li Hong

Molecular dynamics analysis of T567 phosphorylation-induced conformational changes in ezrin

Ezrin, a key member of the ERM (Ezrin–Radixin–Moesin) family, links the plasma membrane to the actin cytoskeleton and is regulated by a conformational switch between closed and open states. Although phosphatidylinositol 4,5-bisphosphate binding and phosphorylation at Thr567 are known to promote Ezrin activation, the as...