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Review Open access Oct 2026

Integrated genomics and metabolomics survey of steroids from myxobacteria

An integrated genomics–metabolomics pipeline is established that not only expands the structural repertoire of myxobacterial steroids but also provides a blueprint for future discovery of cryptic sterol metabolites and their hidden biological functions.

Bing-Jie Fan, Luo Niu, Teng Liu et al. · 0 citations
Open access Jul 2026

Spatial specialization of antioxidant defenses dictates predation success in Myxococcus xanthus

Redox-based chemical warfare is a primary driver of microbial community assembly. Here, we show that the predatory bacterium Myxococcus xanthus employs a spatial division of labor between two inducible monofunctional catalases, mxKatB and mxKatE, to overcome prey-derived hydrogen peroxide (H₂O₂). Quantitative transcrip...

D. Sheng, Xuan-qi Zhang, Xin-yao Yan et al. · 0 citations
#protein folding Open access Aug 2026

Divergent contributions of multiple PPIases to cell survival, sociality, and stress tolerance in Myxococcus xanthus DK1622

ABSTRACT Peptidylprolyl isomerase (PPIase) catalyzes the rate-limiting step of proline cis-trans isomerization during protein folding. In bacteria, multiple PPIases are commonly present and participate in diverse physiological processes. Myxococcus xanthus DK1622 possesses as many as 17 PPIase genes. We previously repo...

Tian-yu Wan, Rui-You Chen, Zi-Ye Zhou et al. · 0 citations

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