Open access
Sep 2026
Targeting NSUN5-mediated m5C-RNA modification overcomes sunitinib resistance in renal cell carcinoma by suppressing Fibronectin/PI3K/AKT signaling
Sunitinib resistance represents a dominating obstacle for clinical pharmacotherapy of renal cell carcinoma (RCC). Dysregulation of the RNA 5-methylcytosine (m 5 C) modification exerts an important influence on tumor pathogenesis, yet its role and the mechanism underlying RCC sunitinib resistance remain unknown. H...
Chan Huang, M. Luo, Neng-Qiao Wen et al.
· Cell Death & Disease · 0 citations