Author

Li-Zhe Zhu

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Open access Aug 2026

Molecular basis of HACD-TECR complex mediated very-long-chain fatty acid elongation reveal a potential target in colorectal cancer

It is demonstrated that trans-2-enoyl-CoA reductase (TECR) is upregulated in colorectal cancer (CRC) and a potential therapeutic strategy for CRC treatment by modulating VLCFA metabolism is suggested.

Rui Lv, Lei-Ye Yu, Jing-Yi Liu et al. · Science Advances · 0 citations

Jul 2026

Designing Fidelity of CRISPR-Cas Endonucleases by Kinetic Insights

A PLM-assisted physics-driven approach is presented that utilizes atomistic molecular dynamics simulations and automated path searching to efficiently obtain the complete kinetic insights, including the transition state structures, for the conformational changes of Cas before DNA cleavage.

Huihui Liu, Zhenyu Zhou, Luowei Yuan et al. · bioRxiv · 0 citations