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Author

Li Yuan

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Preprint Oct 2026

RipplePLM: Structural and Property Decoupling for Protein Mutation Effect Generation

Protein mutation effect generation asks a model to describe the functional consequence of a point mutation in natural language. Existing protein-to-text systems typically encode mutation information into undifferentiated representations, overlooking the organization of mutation-induced evidence across structural and bi...

Liuzhenghao Lv, Yu-Yang Liu, Yu-Yang Gao et al. · 0 citations
Aug 2026

TCRspec: A Recognition Interface-Informed Multimodal Method for TCR-pMHC Specificity Prediction.

TCRspec, an interpretable multimodal framework combining sequence embeddings, gene-usage features, and complex-level structural representations, providing a structure-informed framework for TCR specificity prediction, is developed.

Jia Zou, Zong-Ying Lin, Yi-Min Wang et al. · 0 citations
Open access Jul 2026

Navigating chemical-linguistic sharing space with heterogeneous molecular encoding

HME is presented, a framework that combines multiple views of molecules to improve molecular understanding and design and enables bidirectional navigation of the chemical-linguistic space, achieving consistent improvements across molecular comprehension and design tasks over strong baselines.

Liuzhenghao Lv, Hao Li, Yu Wang et al. · 0 citations

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