Extracellular targeted protein degradation (eTPD) systems typically utilize lysosome-targeting receptors (LTRs) to mediate internalization and lysosomal degradation of extracellular and membrane proteins. While multiple LTRs have been discovered, there remains a compelling need to seek for new LTRs, particularly those...
Lu Chen, Xin-Ying Fu, Wen-Qian Dong et al.· bioRxiv· 0 citations
These findings expand the structural diversity of decalin polyketides and provide the first evidence of antitubercular activity by this compound family.
Junjie Yu, Shangqian Ning, Yuchang Di et al.· Antibiotics· 0 citations
These findings establish TROP2 as a robust LTR and provide a versatile eTPD platform with profound translational potential for tumor treatment, as well as design TRTAC-drug conjugates, enabling targeted protein degradation together with enhanced drug delivery.
TRACER (terpene rearrangement annotation via co-attentive enzyme-product representation), a multimodal framework mapping the latent associations between sequence-derived enzyme representations and product chemotypes, establishes a predictive paradigm for the rational discovery and mechanistic elucidation of complex ter...
