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Author

Lixia Chen

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Review Sep 2026

Comprehensive insights into Astragalus membranaceus polysaccharides: Extraction, structural characteristics, bioactivities, and applications: A review.

Astragalus membranaceus polysaccharides (APS), bioactive macromolecules derived from the roots of Astragalus membranaceus (Fisch.) Bge., exert immunomodulatory, anti-inflammatory, antioxidant, and metabolic regulatory effects. However, the molecular features and compositional profiles of APS are strongly influenced by...

Jing Cheng, Qian-Hui Liu, Rui Zhu et al. · 0 citations
Aug 2026

Discovery of DCAF16-based PROTACs as SHP2 degraders.

The design and synthesis of SHP2 PROTACs that recruit the DCAF16 E3 ligase for targeted SHP2 degradation are reported that support the potential of SHP2-targeted protein degradation as an alternative strategy to enzymatic inhibition and provide a promising starting point for the further development of SHP2 degraders.

X. Pang, Yuxin Gan, Qing-Yuan Hu et al. · 0 citations

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