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Review Open access Oct 2026

Immunotherapy Resistance in Small Cell Lung Cancer: Mechanisms and Therapeutic Vulnerabilities

In small cell lung cancer (SCLC), immune checkpoint inhibitors (ICIs) combined with platinum-based chemotherapy are standard first-line treatment for extensive-stage disease. However, durable disease control remains uncommon. This review examines lineage plasticity, epigenetic regulation, defective antigen presentation...

Li-Wen Xu, Yi-Xuan Cheng, Han-Rui Chen et al. · 1 citation

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