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Li-Wei Wang

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Oct 2026

Highly Enantioselective Synthesis of 1,2,3-Trisubstituted Cyclopropanes through DNA-Catalyzed Johnson–Corey–Chaykovsky Cyclopropanation

Developing enzymatic strategies for diverse reaction manifolds is a major objective in modern biocatalysis. Here, we report the first biocatalytic asymmetric Johnson–Corey–Chaykovsky (JCC) cyclopropanation via DNA catalysis. Unlike conventional small-molecule catalysis, which largely favors trans-cyclopropane formati...

Yang Zheng, Rao Dai, Yun-Lin Li et al. · 0 citations

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