TcTV2 NP combines a predicted phenuivirus-like core with experimentally observed RNA association and heterogeneous ring-like particle formation, while the computational analyses nominate the electropositive groove as a candidate surface for further ligand interaction studies.
Shan Du, Li-Xuan Qi, Wen-Ni Zhang et al.· Life· 0 citations
BACKGROUND AND PURPOSE
The nuclear receptor NR4A1 is a critical node in transcriptional circuits for metabolic adaptation, yet its role in adipocyte progenitor (AP) fate and proliferation is unclear. We sought to define how NR4A1 governs early adipogenesis and adipose tissue plasticity.
EXPERIMENTAL APPROACH
Doxycycl...
Wan-Ning Qiao, Cun Ku, G. V. Naveen Kumar et al.· British Journal of Pharmacol...· 0 citations
This study identifies candidate biomarkers for CMT disease subtypes associated with defects in translational homeostasis and supports eIF2ɑ-ATF4 axis modulation as a promising therapeutic strategy for this disease class.
Mary McMahon, Steve Lianoglou, Sridhar Narayan et al.· bioRxiv· 0 citations
Results reveal an expanded functional repertoire of nairovirus NPs and suggest that NP-mediated RNA discrimination may contribute to viral replication, and support the feasibility of targeting NP for the development of antiviral drugs against emerging nairoviruses.
Zan Li, Shan Du, Feng Gao et al.· Proceedings of the National...· 0 citations
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