Construction and multi-omics validation of a five-gene ferroptosis-based model for predicting prognosis and therapy response in pancreatic ductal adenocarcinoma with immune landscape analysis.
A concise and externally validated five-gene ferroptosis-related prognostic signature was developed, which effectively stratifies survival outcomes in PDAC patients and reflects ferroptosis-associated alterations in tumor proliferation, metabolic reprogramming, immune evasion, and drug response.