Author

Li-Quan Yang

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Open access Aug 2026

Agonist Binding Reshapes the Kinetic Landscape and Allosteric Communication of APLNR Toward Activation-Competent States

APLNR is a therapeutically important G protein-coupled receptor (GPCR) implicated in cardiovascular and metabolic regulation; however, how agonist binding reorganizes receptor dynamics to promote signaling competence remains poorly understood. Here, we used the small-molecule agonist CMF-019 as a representative ligand...

Hong-Xun Dai, Jun-Yao Zhu, Bao Zhang et al. · International Journal of Mol... · 0 citations

Open access Aug 2026

V600E biases the BRAF kinase domain toward an activation-compatible conformational ensemble through long-range dynamic rewiring

A model in which V600E preorganizes the inactive-like BRAF kinase domain toward activation-compatible conformations through conformational reweighting and long-range dynamic rewiring may facilitate oncogenic signaling in the presence of the additional regulatory interactions required for complete kinase activation.

Bao Zhang, Qi Xi, Yu-Meng Ying et al. · RSC Advances · 0 citations

Open access Jul 2026

Temperature-Dependent Reorganization of Conformational Dynamics and Interaction Networks Underlies Thermostability in PET-Degrading Enzymes

Polyethylene terephthalate (PET) is one of the most widely used synthetic plastics and a major contributor to global plastic pollution because of its high resistance to degradation. Enzymatic degradation by PET hydrolases (PETase) has emerged as a sustainable strategy for PET recycling; however, the limited thermostabi...

Hui Duan, Chen Wan, Bu-Qing Wang et al. · International Journal of Mol... · 0 citations