Author

Liqiang Fan

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Open access Aug 2026

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Extracellular targeted protein degradation (eTPD) systems typically utilize lysosome-targeting receptors (LTRs) to mediate internalization and lysosomal degradation of extracellular and membrane proteins. While multiple LTRs have been discovered, there remains a compelling need to seek for new LTRs, particularly those...

Lu Chen, Xin-Ying Fu, Wen-Qian Dong et al. · bioRxiv · 0 citations

Open access Aug 2026

Enhanced heparosan biosynthesis in Corynebacterium glutamicum by systematic metabolic engineering and translation-level fine-tuning

This study systematically engineered Corynebacterium glutamicum, a Generally Recognized as Safe (GRAS) microorganism, to synthesize heparosan via two complementary strategies, which provide valuable references for constructing high-efficiency cell factories for other complex compounds.

Jie Zhang, Ya-Nan Cui, Pei-Yi Zhang et al. · Bioresources and Bioprocessi... · 0 citations

Open access Aug 2026

TROP2-targeting chimeras (TRTACs) for tumor-selective membrane protein degradation and enhanced drug delivery

These findings establish TROP2 as a robust LTR and provide a versatile eTPD platform with profound translational potential for tumor treatment, as well as design TRTAC-drug conjugates, enabling targeted protein degradation together with enhanced drug delivery.

Lu-Ping Chen, Xinying Fu, Wenqian Dong et al. · bioRxiv · 0 citations