Review
Open access
Jul 2026
Substrate-selective mTORC1 regulation and gene dosage–dependent tissue divergence in Birt–Hogg–Dubé syndrome
An integrated pathogenic framework is described that drives renal tumorigenesis via constitutive MiT/TFE nuclear accumulation and metabolic reprogramming and highlights novel therapeutic vulnerabilities targeting MiT/TFE factors and kinase rewiring, providing a rationale for organ-specific precision medicine in BHD.
Z. Cao, Si-Cheng Zhao, Feng Lin et al.
· Frontiers in Oncology · 0 citations