Low-dose radiotherapy ameliorates Alzheimer's-like pathology in 5xFAD mice and is associated with HIF-1α-related inflammatory signaling downregulation.
BACKGROUND Whether fractionated low-dose radiotherapy (LDRT) alleviates Alzheimer's disease-like pathology and whether these effects are associated with microglial HIF-1α-related signaling remain unclear. METHODS Male 5xFAD mice received whole-brain irradiation at 2 Gy per fraction for 5 fractions (total dose, 10 Gy)...