Author

Lina Dong

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Open access Sep 2026

Enhancing biocatalytic retrosynthesis with a graph-to-graph model

Biocatalytic synthesis offers a green and sustainable route for chemical production, yet the rational design of biocatalytic routes remains challenging due to the need to jointly consider reaction feasibility and enzymatic compatibility. Here, we present BioG2G_ESR, a unified framework centered on graph-to-graph modeli...

Li-Na Dong, Lin Yao, Yu-Chen Yang et al. · Chemical Science · 0 citations

Aug 2026

Metal Coordination Dynamics Governs Selective Halogenation in α-KG/Fe-Dependent Halogenase SyrB2.

α-Ketoglutarate (α-KG)-dependent nonheme iron enzymes catalyze a diverse array of oxidative transformations essential for natural product biosynthesis. However, the mechanism by which α-KG/Fe-dependent halogenases achieve selective halogenation while circumventing the thermodynamically favored hydroxylation pathway rem...

Wen-Li Yuan, Jia-Yong Huang, Jia Liu et al. · Angewandte Chemie · 0 citations