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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Li-Min Wang

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Open access Oct 2026

CPNE8 Suppresses Hepatocellular Carcinoma Progression Through Downregulation of ITGB1/CDC42/PAK1 Signaling and an Altered Immune-Marker Profile

Background: Hepatocellular carcinoma (HCC) is among the most lethal malignancies, and its immunosuppressive microenvironment limits the efficacy of current therapies. The integrin β1 (ITGB1)-CDC42-p21-activated kinase 1 (PAK1) axis is an established driver of HCC progression; however, the role of copine 8 (CPNE8), a ca...

Xiao-Fang Zhao, Jing Meng, Li-Min Wang · 0 citations

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